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IUTAM

NSF

Program

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Tuesday, June 17

18:00Welcome Reception

Wednesday, June 18

8:45Opening remarks

Tissue Mechanics (Chair: E. Kuhl)

9:00 Ellen M. Arruda: Experimental and Computational Investigation of Poroviscoelasticity in Native and Engineered Connective Tissue
9:30 T. D. Nguyen: A Microstructure-Based Anisotropic, Nonlinear Viscoelastic Model for Irregular Fibrous Tissues
10:00 P. Ciarletta, A.N. Natali, P.G. Pavan & E.L. Carniel:Hysteretic Behavior of Soft collagenous Tissues: Analysis of Energy Dissipation and Non-recoverable Strain
10:30 BREAK

Cell-substrate Interactions (Chair: E.M. Arruda)

11:00 J.A. Stella, J. Liao, Y. Hong, W.D. Merryman, W.R. Wagner & M.S. Sacks: Tissue-Cellular Deformation Coupling in Cell Microintegrated Elastomeric Scaffolds
11:30 D.E. Discher: Matrix Elasticity Directs Stem Cell Lineage: Experiments & Computational Insights
12:00 R. De, A. Zemel & S.A. Safran: Dynamics of Stress Response of Biological Cells
12:30 LUNCH

Mechanotransduction in Proteins (Chair: D.E. Discher)

13:30 V. Vogel: Tuning the Structure-function Relationship of Extra-and Intracellular Proteins: stretching fibronectin fibers and talin
14:00 M.P. Sheetz: Shaping Cells by Force and Rigidity Though Protein Stretching

Mechanics of DNA (Chair: D.E. Discher)

14:30 S. Goyal, T. Lillian, N.C. Perkins, E. Meyhöfer: Mechanics of DNA Looping by the Lac Repressor Protein: How Stress-free Shape Influences Loop Energetics and Topology
15:00 BREAK
15:30 N. Clauvelin, B. Audoly & S. Neukirch: Magnetic Tweezer Experiments as a Benchmark for Models of DNA-DNA Electrostatic Interaction
16:00 P. Purohit: Torsional Buckling and Plectoneme Formation in Fluctuating DNA
16:30 Y.Y. Biton & B.D. Coleman: On the Theory of the Sequence-dependent Mechanics of DNA Supercoiling with Electrostatic Forces Taken into Account

Thursday, June 19

Morphogenesis (Chair: L. Taber)

8:30 M. Krieg, Y. Arboleda, P.H. Puech, J. Käfer F. Graner, C.P. Heisenberg & D.J. Müller: Deciphering Molecular Forces that Govern Germ layer Organization during Gastrulation
9:00 J. Dervaux & M. Ben Amar: Morphogenesis of Growing Soft Tissues
9:30 S.R. Lubkin: Mechanics in Epithelio-Mesenchymal Interactions
10:00 BREAK
10:30 L.A. Taber: On a Fundamental Principle for Morphomechanics

Cell-substrate Interactions (continued) (Chair: S.A. Safran)

11:00 B. Geiger, S. Winograd-Katz, C. Luxenburg, I. Patela, T. Volberg, J. Spatz, O. Medalia, L. Addadi: The Molecular Organization of Adhesion-signaling Complexes of the Intergrin Adhesome
11:30 S. Jungbauer, H. Gao, J.P. Spatz & R. Kemkemer: Universal Frequency- Dependent Response of Cells Under Cyclical Strain
12:00 J.P. Spatz: Chemo-Mechanical Stimulation of Cells by Nano-Digital Environments
12:30 LUNCH

Posters

13:00-15:00 M. Arslan, S. Cantournet & M. Boyce: Micromechanical Modeling of Microtubules
S. Calve & H.G. Simon: Extracellular Control of Limb Regeneration
C. Castro, A. Hu, H. Pleogh, M. Boyce & M. Lang: B Lymphocyte Membrane Reservoir Mechanics
R. De, A. Zemel & S.A. Safran: Dynamics of Active Cellular Response Under Stress
A.E. Ehret, M. Itskov: A Viscoelastic Anisotropic Model for Soft Collageneous Tissues Based on Distributed Fiber-Matrix Units
R. P. Hoo, W.R. Walsh & M.J. Hoffman: Analysis of Elastic-Viscous-Plastic Deformation Behavior of Cortical Bone Determined by Nanoindentation and Analytical Modelling
S. Jungbauer, H. Gao, J.P. Spatz & R. Kemkemer: Dynamics of Cell Responses to Mechanical Stretching
Alexander Kohlmaier, Parthive Patel, Huaqi Jiang & Bruce Edgar: Tissue Homeostasis by Mechanical Feedback on the Stem Cell Cycle in Vivo?
R.Y. Kwon, A.J. Lew & C.R. Jacobs: A Microstructurally Informed Model for the Mechanical Response of Three-dimensional Actin Networks
J. Ma, K. Goble, T. Kostrominova, L. Larkin, E. Arruda: Morphological and Mechanical Characteristics of Three-Dimensional Engineered Bone-Ligament-Bone Constructs from Rat and Human BMSCs
K.L. Mills, X. Zhu, D. Huh, T. Uchida, S. Takayama & M.D. Thouless: Nanocracking of Plasma-oxidized Polydimethylsiloxane and some Applications in Nano- and Bio-technology
T. Mueller, G. Behme, H. Haschke, W. Dobler & R. Owen: Quantifying Protein-mediated Cell Adhesion by Single Cell Force Spectroscopy
S. Murtada, M. Kroon & G.A. Holzapfel: Mechanical Modelling of Calcium Activated Contraction of Smooth Muscle Cell
J.E. Olberding, M.D. Thouless, E.M. Arruda & K. Garikipati: The Reaction-Limited Regime of Focal Adhesion Dynamics
J.S. Palmer & M. Boyce: Poroviscoelastic Modeling of Cross-linked Actin Filament Networks
R. Paul & U. Schwarz: Pattern Formation and Force Generation by Cell Assembly
R. Vandiver & A. Goriely: Tissue Tension and Axial Growth in Cylindrical Elastic Structures
Y. Wei: Entropic-elasticity-controlled Dissociation and Energetic-elasticity- Controlled Rupture induce catch to slip bonds in Cell-adhesion Molecules
A. Zemel & A. Mogilner: Active Dynamics of Polar Filament Bundles
15:30 EXCURSIONS

Friday, June 20

Mechanics of Biopolymer Networks (Chair: E. Van der Giessen)

8:30 M.C. Boyce, J.S. Palmer, C.E. Castro & M. Arslan: Microstructurally-Informed Constitutive Modeling of the Stress-Strain Behavior of Biological Macromolecular Networks
9:00 F.C. MacKintosh: Non-equilibrium Mechanics and Dynamics of Cytoskeletal Networks
9:30 P.R. Onck, E.M. Huisman, T. van Dillen, E. van der Giessen: The Effect of Network Architecture on the Mechanics of Three-dimensional Cross-linked Actin Networks
10:00 BREAK

Cell Adhesion (Chair: H. Gao)

10:30 L.B. Freund: A Model of the Forced Separation of a Molecular Bond
11:00 J.E. Olberding, M.D. Thouless, E.M. Arruda & K. Garikipati: A Theoretical Study of the Thermodynamics and Kinetics of Focal Adhesion Dynamics
11:30 D. Ambrosi: Cellular Traction on Flat Surfaces: An Inverse Problem in Linear Elasticity
12:00 LUNCH

Growth (Chair: K. Garikipati)

13:00 R. Bernal, E.R. Rojas & J. Dumais: The Mechanics of Tip Growth Morphogenesis: Comparing Experiments and Theory
13:30 E. Kuhl, S. Göktepe, O. Abilez & C.K. Zarins: Dilation and Hypertrophy - A Cell-based Continuum Mechanics Approach Towards Ventricular Growth and Remodeling
14:00 A. Goriely & R. Vandiver: On the Notions of Mechanical Stability and Bifurcation for Growing Elastic Soft Tissues
14:30 BREAK

Mechanics of Biopolymer Networks (continued) (Chair: M.C. Boyce)

15:00 M. Upmanyu, H.L. Wang & L. Mahadevan: Bends and Twists: Stability and Elasticity of Twisted Biopolymers and their Networks
15:30 G. Zagar, P.R. Onck & E. van der Giessen: Effect of Cross-links on the Mechanical Response of Cross-linked Networks
16:00 A.P. Liu, D.L. Richmond, L. Maibaum, P.G. Geissler & D.A. Fletcher: Dynamic Self Assembly of Protrusive Actin Networks on Giant Vesicles
16:30 BREAK
16:45 T. Kim, H. Lee, W. Hwang & R.D. Kamm: Computational and Experimental Modeling of cytoskeletal rheology

Passive Mechanical Response of Proteins (Chair: M.C. Boyce)

17:15 R. Ballarini, Z.L. Shen, M.R. Dodge, S.J. Eppell & H. Kahn: Stress-strain Experiments on Individual Collagen Fibrils
19:00 BANQUET STARTING WITH RECEPTION

Saturday, June 21

Cell Adhesion (Continued) (Chair: L.B. Freund)

8:30 J. Qian, J. Wang & H. Gao: Nanomechanics of Biological Systems - From Single Molecular Bonds to Continuum Mechanics Descriptions of Cell Adhesion
9:00 V.S. Deshpande, A. Pathak, R.M. McMeeking & A.G. Evans: Simulation of the Coupling of Cell Contractility and Focal Adhesion Formation
9:30 U. Schwarz, A. Besser, J. Colombelli & E. Stelzer: Modeling the Coupling between Biochemistry and Mechanics in Cell Adhesion
10:00 BREAK

Cell Adhesion (Continued) (Chair: U. Schwarz)

10:30 R.M. Springman & J.L. Bassani: Mechano-chemical Coupling in the Adhesion of Thin Structures to Surfaces with Topography
11:00 D. Ingber: Mechanobiology and Developmental Control

Poroelasticity of Bone (Chair: U. Schwarz)

11:30 M.L. Oyen: Bone Composite Mechanics Related to Collagen Hydration State
12:00 G.B. Gailani & S.C. Cowin: Russian Doll Poroelasticity; A Model for Fluid Transport in Tissues
12:30 LUNCH
13:30 Open for Discussion

Conference Ends